Ventral tegmental area projections in decision-making

Our research focuses on understanding the role of midbrain neurotransmitter-specific neural projections in the cognitive processes of the hippocampus and mPFC. We use neuroanatomical and functional tracing methods to achieve this, along with high-impedance silicon probe recording (in vivo electrophysiology) and computational analysis methods. In addition, we use Cre-lox recombination and promoter-driven systems to express light-controllable opsin in VTA neural projections. We combine in vivo neural recording and optogenetic modulation of circuits in freely behaving mice to dissect the neural basis of reward and valency-linked behavioral expression. Currently, we are investigating the function of midbrain glutamatergic projections to the hippocampus in novelty learning, context discrimination, and habituation to novel stimuli.